Chemical studies of peripheral nerve during Wallerian degeneration. 4. Phosphatases
نویسندگان
چکیده
منابع مشابه
Critical signaling pathways during Wallerian degeneration of peripheral nerve
Wallerian degeneration is a critical biological process that occurs in distal nerve stumps after nerve injury. To systematically investigate molecular changes underlying Wallerian degeneration, we used a rat sciatic nerve transection model to examine microarray analysis outcomes and investigate significantly involved Kyoto Enrichment of Genes and Genomes (KEGG) pathways in injured distal nerve ...
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We used anti-phosphopeptide-immunodetecting antibodies as immunohistochemical reagents to define the location and activity state of p185(erbB2) during Wallerian degeneration. Nerve damage induces a phosphorylation event at Y1248, a site that couples p185(erbB2) to the Ras-Raf-MAP kinase signal transduction pathway. Phosphorylation of p185(erbB2) occurs within Schwann cells and coincides in time...
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When a myelinated nerve fiber is interrupted, its distal portion undergoes Wallerian degeneration, which involves the disruption and removal of the axon and myelin. Although a number of electron microscope studies on Wallerian degeneration have been published (1-6), insufficient information is so far available for a systematic description of the process of myelin breakdown and removal to be mad...
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Conduction in the lateral popliteal nerve of the baboon was studied during the course of Wallerian degeneration. Six nerves were examined. In each case the muscle response to nerve stimulation and the ascending nerve action potential were recorded daily until the nerve became inexcitable. The muscle response to nerve stimulation disappeared after four to five days, but ascending nerve action po...
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Wallerian degeneration is an innate immune response which occurs after some kinds of nerve damages such as neurodegenerative disease and acute axonal injury. In clinic, dexamethasone as an anti-inflammatory drug has been used for many years to treat nerve injuries. In present study, we aimed to study the effects of various doses of dexamethasone on the Wallerian degeneration in rat. Twentyseven ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1952
ISSN: 0306-3283
DOI: 10.1042/bj0520652